WO2009111676A3 - Boron-containing small molecules as anti-inflammatory agents - Google Patents

Boron-containing small molecules as anti-inflammatory agents Download PDF

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Publication number
WO2009111676A3
WO2009111676A3 PCT/US2009/036250 US2009036250W WO2009111676A3 WO 2009111676 A3 WO2009111676 A3 WO 2009111676A3 US 2009036250 W US2009036250 W US 2009036250W WO 2009111676 A3 WO2009111676 A3 WO 2009111676A3
Authority
WO
WIPO (PCT)
Prior art keywords
boron
small molecules
inflammatory agents
containing small
inflammatory
Prior art date
Application number
PCT/US2009/036250
Other languages
French (fr)
Other versions
WO2009111676A2 (en
WO2009111676A8 (en
Inventor
Tsutomu Akama
Yong-Kang Zhang
Charles Z. Ding
Jacob J. Plattner
Kirk R. Maples
Yvonne Freund
Virginia Sanders
Yi Xia
Stephen J. Baker
James A Niemann
Xiaosong Lu
Marcelo Sales
Rashmi Sharma
Rajeshwar Singh
Robert Jacobs
Daitao Chen
Michael Richard Kevin Alley
Original Assignee
Anacor Pharmaceuticals, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2010549900A priority Critical patent/JP5745279B2/en
Priority to CN2009801162797A priority patent/CN102014927A/en
Priority to CA 2718170 priority patent/CA2718170A1/en
Priority to RU2010140803/04A priority patent/RU2547441C2/en
Application filed by Anacor Pharmaceuticals, Inc filed Critical Anacor Pharmaceuticals, Inc
Priority to NZ58795509A priority patent/NZ587955A/en
Priority to KR1020107022132A priority patent/KR101672511B1/en
Priority to AU2009221793A priority patent/AU2009221793B2/en
Priority to KR1020157014083A priority patent/KR20150065941A/en
Priority to MX2010009765A priority patent/MX2010009765A/en
Priority to EP09700012A priority patent/EP2187893A4/en
Priority to BRPI0908565A priority patent/BRPI0908565A2/en
Publication of WO2009111676A2 publication Critical patent/WO2009111676A2/en
Publication of WO2009111676A3 publication Critical patent/WO2009111676A3/en
Priority to IL207955A priority patent/IL207955A/en
Publication of WO2009111676A8 publication Critical patent/WO2009111676A8/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds

Abstract

Compounds and methods of treating anti-inflammatory conditions are disclosed.
PCT/US2009/036250 2008-01-09 2009-03-05 Boron-containing small molecules as anti-inflammatory agents WO2009111676A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR1020107022132A KR101672511B1 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
CA 2718170 CA2718170A1 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
RU2010140803/04A RU2547441C2 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
KR1020157014083A KR20150065941A (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
NZ58795509A NZ587955A (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
CN2009801162797A CN102014927A (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
AU2009221793A AU2009221793B2 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
JP2010549900A JP5745279B2 (en) 2008-01-09 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
MX2010009765A MX2010009765A (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents.
EP09700012A EP2187893A4 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
BRPI0908565A BRPI0908565A2 (en) 2008-03-06 2009-03-05 compound, pharmaceutical formulation, methods for reducing the release of a cytokine or chemokine, treating a condition in an animal and inhibiting a phosphodiesterase
IL207955A IL207955A (en) 2008-03-06 2010-09-02 Boron-containing small molecules as anti-inflammatory agents

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US61/143,700 2008-01-09
US61/148,731 2008-01-30
US3437108P 2008-03-06 2008-03-06
US61/034,371 2008-03-06
US5263708P 2008-05-12 2008-05-12
US61/052,637 2008-05-12
US9440608P 2008-09-04 2008-09-04
US61/094,406 2008-09-04
US10599008P 2008-10-16 2008-10-16
US61/105,990 2008-10-16
US11090308P 2008-11-03 2008-11-03
US61/110,903 2008-11-03
US14370009P 2009-01-09 2009-01-09
US14873109P 2009-01-30 2009-01-30

Publications (3)

Publication Number Publication Date
WO2009111676A2 WO2009111676A2 (en) 2009-09-11
WO2009111676A3 true WO2009111676A3 (en) 2010-04-01
WO2009111676A8 WO2009111676A8 (en) 2010-09-30

Family

ID=41056660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/036250 WO2009111676A2 (en) 2008-01-09 2009-03-05 Boron-containing small molecules as anti-inflammatory agents

Country Status (2)

Country Link
EP (1) EP2187893A4 (en)
WO (1) WO2009111676A2 (en)

Families Citing this family (40)

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EP1853251B1 (en) 2005-02-16 2013-04-24 Anacor Pharmaceuticals, Inc. Halogen-substituted boronophthalides for the treatment of infections
WO2007078340A2 (en) 2005-12-30 2007-07-12 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
KR20130120552A (en) 2006-02-16 2013-11-04 아나코르 파마슈티칼스 인코포레이티드 Boron-containing small molecules as anti-inflammatory agents
RU2547441C2 (en) 2008-03-06 2015-04-10 Анакор Фармасьютикалз, Инк. Boron-containing small molecules as anti-inflammatory agents
WO2010028005A1 (en) 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010027975A1 (en) 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010045503A1 (en) 2008-10-15 2010-04-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
EP2378886A4 (en) 2008-12-17 2012-08-29 Anacor Pharmaceuticals Inc Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
US8343944B2 (en) 2009-07-28 2013-01-01 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
US9440994B2 (en) 2009-08-14 2016-09-13 Anacor Pharmaceuticals, Inc. Boron containing small molecules as antiprotozoal agents
WO2011022337A1 (en) 2009-08-19 2011-02-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US9346834B2 (en) 2009-10-20 2016-05-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US8461134B2 (en) 2009-11-11 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011063293A1 (en) * 2009-11-20 2011-05-26 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antihelminth agents
US8716478B2 (en) 2010-01-27 2014-05-06 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8623911B2 (en) 2010-03-19 2014-01-07 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agent
AU2011299243C1 (en) * 2010-09-07 2016-06-02 Anacor Pharmaceuticals, LLC. Benzoxaborole derivatives for treating bacterial infections
SI2744332T1 (en) 2011-08-19 2017-01-31 Glaxo Group Limited Benzofuran compounds for the treatment of hepatitis c virus infections
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
DK2950644T3 (en) 2013-01-30 2017-09-04 Agrofresh Inc USE OF BENZOXABOROLS AS VOLATIVE ANTIMICROBIAL AGENTS IN MEAT, PLANTS OR PARTS
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
WO2016001834A1 (en) 2014-07-01 2016-01-07 Daiichi Sankyo Company, Limited Tricyclic benzoxaboroles as antibacterial agents
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
EP3383363B1 (en) 2015-11-30 2021-01-06 Anacor Pharmaceuticals, Inc. Topical pharmaceutical formulations for treating inflammatory-related conditions
AU2017229098B2 (en) 2016-03-07 2021-05-27 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
US11447506B2 (en) 2016-05-09 2022-09-20 Anacor Pharmaceuticals, Inc. Crystal forms of crisaborole in free form and preparation method and use thereof
WO2017203514A1 (en) * 2016-05-26 2017-11-30 Perrigo Api Ltd Polymorphs of crisaborole and production processes therefor
WO2018160845A1 (en) 2017-03-01 2018-09-07 Anacor Pharmaceuticals, Inc. Novel oxaborole analogs and uses thereof
WO2018207216A1 (en) * 2017-05-12 2018-11-15 Biophore India Pharmaceuticals Pvt. Ltd. Novel process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (crisaborole)
WO2018216032A1 (en) * 2017-05-23 2018-11-29 Msn Laboratories Private Limited, R&D Center Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof
MX2020005464A (en) 2017-11-30 2020-12-03 Boragen Inc Benzoxaborole compounds and formulations thereof.
AU2019325436B2 (en) 2018-08-18 2023-10-26 5Metis, Inc. Solid forms of substituted benzoxaborole and compositions thereof
SG11202102674RA (en) 2018-10-05 2021-04-29 Pfizer Boron containing pde4 inhibitors
CN113543852A (en) 2019-03-06 2021-10-22 第一三共株式会社 Pyrrolopyrazole derivatives
CN112174989B (en) * 2019-07-02 2023-06-20 江西同和药业股份有限公司 Preparation method of clenbuterol
WO2022043936A1 (en) 2020-08-31 2022-03-03 Pfizer Inc. Methods of protecting rna
WO2024038090A1 (en) * 2022-08-18 2024-02-22 Mitodicure Gmbh Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance
CN116239498B (en) * 2023-05-11 2023-07-21 北京元延医药科技股份有限公司 Method for preparing clenbuterol intermediate

Citations (3)

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US6800845B2 (en) * 2000-02-22 2004-10-05 Ricoh Company, Ltd. Multi-beam scanning device, multi-beam scanning method, light source device, and image forming apparatus
US20060222671A1 (en) * 2005-03-30 2006-10-05 Astion Development A/S Dermatological compositions and salts for the treatment of dermatological diseases
US20070293457A1 (en) * 2006-02-16 2007-12-20 Baker Stephen J Boron-containing small molecules as anti-inflammatory agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1853251B1 (en) * 2005-02-16 2013-04-24 Anacor Pharmaceuticals, Inc. Halogen-substituted boronophthalides for the treatment of infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800845B2 (en) * 2000-02-22 2004-10-05 Ricoh Company, Ltd. Multi-beam scanning device, multi-beam scanning method, light source device, and image forming apparatus
US20060222671A1 (en) * 2005-03-30 2006-10-05 Astion Development A/S Dermatological compositions and salts for the treatment of dermatological diseases
US20070293457A1 (en) * 2006-02-16 2007-12-20 Baker Stephen J Boron-containing small molecules as anti-inflammatory agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2187893A4 *

Also Published As

Publication number Publication date
EP2187893A2 (en) 2010-05-26
WO2009111676A2 (en) 2009-09-11
EP2187893A4 (en) 2012-02-22
WO2009111676A8 (en) 2010-09-30

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